Showing posts with label pregabalin. Show all posts
Showing posts with label pregabalin. Show all posts

Tuesday 15 September 2015

Pregabalin


Figure imgf000006_0004
Figure imgf000006_0005
15 16 (S)-Pregabalin
Figure imgf000010_0001
Figure imgf000011_0001

Example 7: Preparation of (S) Pregabalin from compound 19
1Og of compound 19 is dissolved in 440 ml 6 N HCl, and the solution is warmed to 125°C for 15 hours. After cooling, the mixture is diluted with water, and extracted three times with dichloromethane, then the aqueous phase is evaporated. After drying under high vacuum, the (S)-Pregabalin hydrochloride is obtained as crystals. (S)-Pregabalin is further resolved by dissolving (S)-Pregabalin hydrochloride in isobutanol, and then adding triethyl amine. The mixture is stirred for 45 minutes, and the product is filtered, washed with isobutanol.

Publication numberWO2006110783 A2
Publication typeApplication
Application numberPCT/US2006/013565
Publication dateOct 19, 2006
Filing dateApr 11, 2006
Priority dateApr 11, 2005
Also published asCA2603215A14 More »
InventorsAsher MaymonVinod Kumar KansalLilach Hedvati
ApplicantTeva PharmaAsher MaymonVinod Kumar KansalLilach Hedvati
Export CitationBiBTeXEndNoteRefMan
External Links: PatentscopeEspacenet










Citing PatentFiling datePublication dateApplicantTitle
WO2008007145A2 *Jul 12, 2007Jan 17, 2008Generics Uk LtdProcess of preparing a gamma-amino acid
WO2008117305A2 *Mar 3, 2008Oct 2, 2008Venkata Siva Kumar BobbaA novel process for preparing pregabalin and its acid addition salts
WO2009010554A1 *Jul 17, 2008Jan 22, 2009Esteve Labor DrProcess for the enantioselective preparation of pregabalin
WO2009022839A2 *Aug 11, 2008Feb 19, 2009Korea Advanced Inst Sci & TechNovel method for preparing pregabalin
WO2009080365A1 *Dec 18, 2008Jul 2, 2009Synthon BvPregabalin salts
WO2009081208A1 *Dec 19, 2008Jul 2, 2009Generics Uk LtdProcesses to pregabalin
WO2009087650A2 *Oct 14, 2008Jul 16, 2009Sundeep AuroraA novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin
WO2009141362A2 *May 19, 2009Nov 26, 2009Sandoz AgProcess for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
WO2009147434A1 *Jun 3, 2009Dec 10, 2009Generics [Uk] LimitedA novel and efficient method for the synthesis of an amino acid
WO2009149928A1 *Jun 10, 2009Dec 17, 2009Synthon B.V.Processes for making pregabalin and intermediates therefor
WO2014005494A1 *Jun 28, 2013Jan 9, 2014Sunshine Lake Pharma Co., Ltd.Method of preparing lactam compound
EP2017273A1 *Jul 18, 2007Jan 21, 2009Laboratorios del Dr. Esteve S.A.Process for the enantioselective preparation of pregabalin
US7586005Oct 28, 2008Sep 8, 2009Teva Pharmaceutical Industries Ltd.Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US7619112Aug 14, 2007Nov 17, 2009Teva Pharmaceutical Industries Ltd.Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
US7678938Aug 14, 2007Mar 16, 2010Teva Pharmaceutical Industries Ltd.Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
US7763749May 10, 2006Jul 27, 2010Teva Pharmaceutical Industries Ltd.Method for the preparation of Pregabalin and salts thereof
US7851651Oct 28, 2008Dec 14, 2010Teva Pharmaceutical Industries Ltd.Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US7923575Oct 19, 2009Apr 12, 2011Teva Pharmaceutical Industries LimitedAsymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US7960583Oct 28, 2008Jun 14, 2011Teva Pharmaceutical Industries Ltd.Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US7973196Aug 30, 2010Jul 5, 2011Teva Pharmaceutical Industries Ltd.Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US8097754Mar 24, 2008Jan 17, 2012Teva Pharmaceutical Industries Ltd.Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
US8212071Nov 4, 2008Jul 3, 2012Teva Pharmaceutical Industries Ltd.Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US8546112May 19, 2009Oct 1, 2013Sandoz AgProcess for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester